Immuno-Oncology in China
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Clinical Trial Results

旨在评估 Vorolanib 在晚期实体肿瘤患者中的安全性、耐受性和药代动力学的首次应用于人体的 I 期剂量递增研究
Phase I, First‐in‐Human, Dose‐Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Vorolanib in Patients with Advanced Solid Tumors
Johanna C. Bendell, Manish R. Patel, Kathleen N. Moore, Cynthia C. Chua, Hendrik‐Tobias Arkenau, Gary Dukart, Kim Harrow, Chris Liang
The Oncologist 2019; 24:455-e121; first published on November 26, 2018; doi:10.1634/theoncologist.2018-0740

关于贝伐单抗联合多西他赛和吉西他滨治疗初治非鳞状非小细胞肺癌的开放标签 II 期试验
An Open‐Label Phase II Trial of Bevacizumab plus Docetaxel and Gemcitabine in Advanced, Previously Untreated Nonsquamous Non‐Small Cell Lung Cancer
Pradnya Dinkar Patil, Marc Shapiro, Nooshin Hashemi Sadraei, Nathan A. Pennell
The Oncologist 2019; 24:457-e126; first published on January 2, 2019; doi:10.1634/theoncologist.2018-0857

S-1 和紫杉醇联合作为晚期非小细胞肺癌老年患者一线治疗的 II 期研究
A Phase II Study of S‐1 and Paclitaxel Combination Therapy as a First‐Line Treatment in Elderly Patients with Advanced Non‐Small Cell Lung Cancer
Akihiro Yoshimura, Yusuke Chihara, Koji Date, Nobuyo Tamiya, Yoshizumi Takemura, Tatsuya Imabayashi, Yoshiko Kaneko, Tadaaki Yamada, Mikio Ueda, Taichiro Arimoto, Junji Uchino, Yoshinobu Iwasaki, Koichi Takayama
The Oncologist 2019; 24:459-e131; first published on December 21, 2018; doi:10.1634/theoncologist.2018-0858

内皮抑素联合奥沙利铂为基础的放化疗治疗不可手术的食管鳞状细胞癌:II 期研究结果
Endostatin and Oxaliplatin‐Based Chemoradiotherapy for Inoperable Esophageal Squamous Cell Carcinoma: Results of a Phase II Study
Wenxin Li, Peng Chen, Ni Zhang, Tao Song, Shixiu Wu
The Oncologist 2019; 24:461-e136; first published on March 8, 2019; doi:10.1634/theoncologist.2019-0119


Gastrointestinal Cancer

兰瑞肽储库型控释注射/凝胶注射对非功能性转移性肠胰神经内分泌肿瘤患者的尿 5-羟基吲哚乙酸及血浆嗜铬粒蛋白 A 生物标志物的影响
Effect of Lanreotide Depot/Autogel on Urinary 5‐Hydroxyindoleacetic Acid and Plasma Chromogranin A Biomarkers in Nonfunctional Metastatic Enteropancreatic Neuroendocrine Tumors
Marianne E. Pavel, Alexandria T. Phan, Edward M. Wolin, Beloo Mirakhur, Nilani Liyanage, Susan Pitman Lowenthal, George A. Fisher Jr, Aaron I. Vinik, on behalf of CLARINET Study Investigators
The Oncologist 2019; 24:463-474; first published on October 24, 2018; doi:10.1634/theoncologist.2018-0217

关于二线 FOLFIRI 联合雷莫芦单抗治疗晚期胃食管腺癌的初步报告:多机构回顾性分析
Initial Report of Second‐Line FOLFIRI in Combination with Ramucirumab in Advanced Gastroesophageal Adenocarcinomas: A Multi‐Institutional Retrospective Analysis
Samuel J. Klempner, Steven B. Maron, Leah Chase, Samantha Lomnicki, Zev A. Wainberg, Daniel V.T. Catenacci
The Oncologist 2019; 24:475-482; first published on November 23, 2018; doi:10.1634/theoncologist.2018-0602

入住重症监护室的晚期胃肠道恶性肿瘤患者的生存预测因子
Predictors of Survival in Patients with Advanced Gastrointestinal Malignancies Admitted to the Intensive Care Unit
Heidi Ko, Melissa Yan, Rohan Gupta, Kayla Kebbel, Abhishek Maiti, Juhee Song, Joseph Nates, Michael J. Overman
The Oncologist 2019; 24:483-490; first published on December 5, 2018; doi:10.1634/theoncologist.2018-0328


Global Health and Cancer

国家综合癌症网络指南建议背后的证据与制药行业给作者的付款
Evidence Underlying Recommendations and Payments from Industry to Authors of the National Comprehensive Cancer Network Guidelines
Xu Liu, Ling‐Long Tang, Yan‐Ping Mao, Qing Liu, Ying Sun, Lei Chen, Jin‐Ching Lin, Jun Ma
The Oncologist 2019; 24:498-504; first published on November 20, 2018; doi:10.1634/theoncologist.2017-0655

表皮生长因子受体 (EGFR) 突变检测:巴西分子检测模式变化
EGFR Mutation Testing: Changing Patterns of Molecular Testing in Brazil
Sofia Palacio, Luciola Pontes, Edna Prado, Junaid Arshad, Robert Ali, Tony Piha, Carlos Eduardo Bacchi, Raja Mudad, Gilberto Lopes
The Oncologist 2019; 24:e137-e141; first published on November 16, 2018; doi:10.1634/theoncologist.2018-0254


Regulatory Issues: FDA

FDA 批准摘要:阿特朱单抗或帕博利珠单抗用于治疗无法接受含顺铂化疗的晚期尿路上皮癌患者
FDA Approval Summary: Atezolizumab or Pembrolizumab for the Treatment of Patients with Advanced Urothelial Carcinoma Ineligible for Cisplatin‐Containing Chemotherapy
Daniel L. Suzman, Sundeep Agrawal, Yang‐min Ning, V. Ellen Maher, Laura L. Fernandes, Stella Karuri, Shenghui Tang, Rajeshwari Sridhara, Jason Schroeder, Kirsten B. Goldberg, Amna Ibrahim, Amy E. McKee, Richard Pazdur, Julia A. Beaver
The Oncologist 2019; 24:563-569; first published on December 12, 2018; doi:10.1634/theoncologist.2018-0084