Clinical Trial Results
临床试验结果


国际期刊《肿瘤学家》杂志旗下Clinical Trial Results (CTR)平台以共享成果,助力科研为使命。基于每个临床试验,不论其最终结果如何,都会给研究者带来获益的信念,《肿瘤学家》杂志致力于领衔建立共享平台以发布所有临床试验结果。

我们邀请您探索本期精选的CTR,共享成果,助力科研。从新药的I期可行性临床试验到对联合治疗方案的有效性和耐受性进行研究的大样本II期临床试验,CTR对不同的治疗方案提供有益的见解,这些方案有些成功了,有些失败了,但他们都对未来研究有所裨益。

Clinical Trial Results (CTR) from The Oncologist promotes the mission of sharing results to speed discoveries. Motivated by the belief that every trial, regardless of outcome, can have a benefit to the research community, The Oncologist has taken a leadership role in providing a forum for the publication of all trials.

We invite you to explore this selection of Clinical Trial Results published in support of this mission. From phase I feasibility studies of novel agents to larger-scale phase II trials studying efficacy and tolerability of combination therapies, CTR offers helpful insights into a variety of therapeutic approaches, some successful, others not, but all of which can inform future research.



在晚期肾细胞癌受试者中联合使用贝伐珠单抗与伊沙匹隆的一项II期、多中心研究
A Phase II Multi‐Center Study of Bevacizumab in Combination with Ixabepilone in Subjects with Advanced Renal Cell Carcinoma

Mauricio Burotto, Maureen Edgerly, Margarita Velarde, Sanjeeve Balasubramaniam, Harry Drabkin, Juan G. Gormaz, Ciara O'Sullivan, Ravi Madan, Tito Fojo
The Oncologist first published on July 5, 2017; doi:10.1634/theoncologist.2017-0211
http://theoncologist.alphamedpress.org/content/22/8/888.abstract.zh

IV期黑色素瘤患者中伴或不伴射频消融或冷冻消融的内源性热休克蛋白诱导
Endogenous Heat‐Shock Protein Induction with or Without Radiofrequency Ablation or Cryoablation in Patients with Stage IV Melanoma

Evidio Domingo‐Musibay, James M. Heun, Wendy K. Nevala, Matthew Callstrom, Thomas Atwell, Evanthia Galanis, Lori A. Erickson, Svetomir N. Markovic
The Oncologist first published on July 5, 2017; doi:10.1634/theoncologist.2017-0060
http://theoncologist.alphamedpress.org/content/early/2017/07/05/theoncologist.2017-0060

一项在携带KRAS突变的既往经治局部晚期或转移性癌症患者中评价Cobimetinib和Duligotuzumab的安全性、耐受性和药代动力学的Ib期剂量递增研究
A Phase Ib Dose‐Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Cobimetinib and Duligotuzumab in Patients with Previously Treated Locally Advanced or Metastatic Cancers with Mutant KRAS

Christopher H. Lieu, Manuel Hidalgo, Jordan D. Berlin, Andrew H. Ko, Andres Cervantes, Patricia LoRusso, David E. Gerber, J. Paul Eder, S. Gail Eckhardt, Amy V. Kapp, Amy Tsuhako, Bruce McCall, Andrea Pirzkall, Anne Uyei, Josep Tabernero
The Oncologist first published on June 7, 2017; doi:10.1634/theoncologist.2017-0175
http://theoncologist.alphamedpress.org/content/early/2017/06/13/theoncologist.2017-0175

Phase II Study of First-Line Trebananib Plus Sorafenib in Patients with Advanced Hepatocellular Carcinoma
Ghassan K. Abou-Alfa, Jean-Frederic Blanc, Steven Miles, Tom Ganten, Jörg Trojan, Jonathan Cebon, Andre K. Liem, Lara Lipton, Charu Gupta, Benjamin Wu, Michael Bass, Ellen Hollywood, Jennifer Ma, Margaret Bradley, Jason Litten, Leonard B. Saltz
The Oncologist 2017; 22:780-e65; first published on June 7, 2017; doi:10.1634/theoncologist.2017-0058
http://theoncologist.alphamedpress.org/cgi/content/full/22/7/780

Ramucirumab治疗中国晚期实体瘤患者的I期剂量递增研究
Phase I Dose-Escalation Study of Ramucirumab in Chinese Patients with Advanced Solid Tumors

Junning Cao, Dongmei Ji, Zhiyu Chen, Weina Shen, Jin Wang, Baoyue Li, Haidong Chi, Amanda Long, Ling Gao, Jin Li
The Oncologist 2017; 22:638-e56; first published on May 2, 2017; doi:10.1634/theoncologist.2017-0137
http://theoncologist.alphamedpress.org/content/22/6/638.abstract.zh

索拉非尼(BAY 43-9006)治疗卡波西肉瘤患者的Ib期研究
A Phase Ib Study of Sorafenib (BAY 43-9006) in Patients with Kaposi Sarcoma

Thomas S. Uldrick, Priscila H. Goncalves, Kathleen M. Wyvill, Cody J. Peer, Wendy Bernstein, Karen Aleman, Mark N. Polizzotto, David Venzon, Seth M. Steinberg, Vickie Marshall, Denise Whitby, Richard F. Little, John J. Wright, Michelle A. Rudek, William D. Figg, Robert Yarchoan
The Oncologist 2017; 22:505-e49; first published on March 24, 2017; doi:10.1634/theoncologist.2016-0486
http://theoncologist.alphamedpress.org/content/22/5/505.abstract.zh

一项Simtuzumab或安慰剂联合吉西他滨一线治疗胰腺腺癌的II期、随机、双盲、安慰剂对照研究
A Phase II Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First-Line Treatment of Pancreatic Adenocarcinoma

Al B. Benson, III, Zev A. Wainberg, J. Randolph Hecht, Dmitry Vyushkov, Hua Dong, Johanna Bendell, Fred Kudrik
The Oncologist 2017; 22:241-e15; first published on February 28, 2017; doi:10.1634/theoncologist.2017-0024
http://theoncologist.alphamedpress.org/content/22/3/241.abstract.zh

醋酸阿比特龙联合泼尼松治疗转移性前列腺癌黑人男性患者的II期临床试验
Phase II Trial of Abiraterone Acetate Plus Prednisone in Black Men With Metastatic Prostate Cancer

Che-Kai Tsao, John Sfakianos, Bobby Liaw, Kiev Gimpel-Tetra, Margaret Kemeny, Linda Bulone, Mohammad Shahin, William Kyu Oh, Matthew David Galsky
The Oncologist 2016; 21:1414-e9; first published on October 14, 2016; doi:10.1634/theoncologist.2016-0026
http://theoncologist.alphamedpress.org/content/21/12/1414.abstract.zh

卡巴他赛与甲氨蝶呤用于曾接受含铂方案治疗的复发性和/或转移性头颈鳞癌患者:随机II期研究
Randomized Phase II Study of Cabazitaxel Versus Methotrexate in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Previously Treated With Platinum-Based Therapy

Jean-Pascal Machiels, Aline Van Maanen, Jean-Marie Vandenbulcke, Bertrand Filleul, Emmanuel Seront, Stéphanie Henry, Lionel D’Hondt, Christophe Lonchay, Stéphane Holbrechts, Petra Boegner, Dany Brohee, Didier Dequanter, Ingrid Louviaux, Brieuc Sautois, Nicolas Whenham, Guy Berchem, Brigitte Vanderschueren, Christel Fontaine, Sandra Schmitz, Aline Gillain, Joelle Schoonjans, Sylvie Rottey
The Oncologist 2016; 21:1416-e17; first published on November 30, 2016; doi:10.1634/theoncologist.2016-0296
http://theoncologist.alphamedpress.org/content/21/12/1416.abstract.zh

组蛋白去乙酰化酶抑制剂帕比司他治疗低级别神经内分泌瘤的II期临床试验
A Phase II Trial of a Histone Deacetylase Inhibitor Panobinostat in Patients With Low-Grade Neuroendocrine Tumors

Ning Jin, Sam J. Lubner, Daniel L. Mulkerin, Saurabh Rajguru, Lakeesha Carmichael, Herb Chen, Kyle D. Holen, Noelle K. LoConte
The Oncologist 2016; 21:785-786g; first published on June 3, 2016; doi:10.1634/theoncologist.2016-0060
http://theoncologist.alphamedpress.org/content/21/7/785.abstract.zh