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Precision Medicine Clinic: Molecular Tumor Board

循环肿瘤 DNA CAPP-Seq 分析在第一代或第二代 EGFR-TKI耐药非小细胞肺癌患者中的基因谱分析作用
Genetic Profiling of Non‐Small Cell Lung Cancer at Development of Resistance to First‐ or Second‐Generation EGFR‐TKIs by CAPP‐Seq Analysis of Circulating Tumor DNA
Kohei Otsubo, Kazuko Sakai, Masafumi Takeshita, Daijiro Harada, Koichi Azuma, Keiichi Ota, Hiroaki Akamatsu, Koichi Goto, Atsushi Horiike, Takayasu Kurata, Noriaki Nakagaki, Kaname Nosaki, Eiji Iwama, Yoichi Nakanishi, Kazuto Nishio, Isamu Okamoto
The Oncologist 2019; 24:1022-1026; first published on April 25, 2019; doi:10.1634/theoncologist.2019-0101

Clinical Trial Results

胸部放疗联合 EGFR-TKI 在 EGFR 活性突变的 IV 期非小细胞肺癌患者一线治疗中的疗效
Concurrent EGFR‐TKI and Thoracic Radiotherapy as First‐Line Treatment for Stage IV Non‐Small Cell Lung Cancer Harboring EGFR Active Mutations
LinPeng Zheng, Yanmei Wang, Zihan Xu, Qiao Yang, Guangkuo Zhu, Xing‐Yun Liao, Xiewan Chen, Bo Zhu, Yuzhong Duan, Jianguo Sun
The Oncologist 2019; 24:1031-e612; first published on April 30, 2019; doi:10.1634/theoncologist.2019-0285

S-1 与紫杉醇联合治疗经治非小细胞肺癌的 II 期研究
Phase II Study of S‐1 and Paclitaxel Combination Therapy in Patients with Previously Treated Non‐Small Cell Lung Cancer
Yusuke Chihara, Akihiro Yoshimura, Koji Date, Yoshizumi Takemura, Nobuyo Tamiya, Yoshihito Kohno, Tatsuya Imabayashi, Mayumi Takeuchi, Yoshiko Kaneko, Tadaaki Yamada, Mikio Ueda, Taichiro Arimoto, Junji Uchino, Yoshinobu Iwasaki, Koichi Takayama
The Oncologist 2019; 24:1033-e617; first published on April 30, 2019; doi:10.1634/theoncologist.2019-0290

苯达莫司汀和奥法单抗在不适合 R-CHOP 化疗的初诊弥漫大 B 细胞淋巴瘤老年患者的 II 期研究
Phase II Study of Bendamustine and Ofatumumab in Elderly Patients with Newly Diagnosed Diffuse Large B‐Cell Lymphoma Who Are Poor Candidates for R‐CHOP Chemotherapy
Ian W. Flinn, Jack Erter, Davey B. Daniel, Joseph R. Mace, Jesus G. Berdeja
The Oncologist 2019; 24:1035-e623; first published on May 9, 2019; doi:10.1634/theoncologist.2019-0286

首次应用于人体的 GC1118(一种新型抗表皮生长因子受体抗体)治疗晚期实体瘤患者的 I 期研究
A First‐in‐Human Phase I Study of GC1118, a Novel Anti‐Epidermal Growth Factor Receptor Antibody, in Patients with Advanced Solid Tumors
Do‐Youn Oh, Keun‐Wook Lee, Sae‐Won Han, Jin Won Kim, Jung‐Won Shin, Seong‐Jin Jo, Jonghwa Won, Seokyung Hahn, Howard Lee, Woo Ho Kim, Yung‐Jue Bang
The Oncologist 2019; 24:1037-e636; first published on June 4, 2019; doi:10.1634/theoncologist.2019-0294

多西他赛、奥沙利铂及 5-氟尿嘧啶(DOF) 用于转移性和不可切除性胃/胃食管结合部腺癌的治疗:一项长期随访的II期研究
Docetaxel, Oxaliplatin, and 5‐Fluorouracil (DOF) in Metastatic and Unresectable Gastric/Gastroesophageal Junction Adenocarcinoma: A Phase II Study with Long‐Term Follow‐Up
Ari Joseph Rosenberg, Alfred Rademaker, Howard S. Hochster, Theresa Ryan, Thomas Hensing, Veena Shankaran, Lisa Baddi, Devalingam Mahalingam, Mary F. Mulcahy, Al B. Benson III
The Oncologist 2019; 24:1039-e642; first published on May 28, 2019; doi:10.1634/theoncologist.2019-0330


Breast Cancer

单药化疗对晚期浸润性小叶癌患者的有效性:关于三项临床试验的汇总分析
Efficacy of Single‐Agent Chemotherapy for Patients with Advanced Invasive Lobular Carcinoma: A Pooled Analysis from Three Clinical Trials
José Pérez‐Garcia, Javier Cortés, Otto Metzger Filho
The Oncologist 2019; 24:1041-1047; first published on December 21, 2018; doi:10.1634/theoncologist.2018-0182

绝经后早期乳腺癌患者使用芳香化酶抑制剂与新发非酒精性脂肪肝之间的关系:倾向性评分匹配队列研究
Aromatase Inhibitors and Newly Developed Nonalcoholic Fatty Liver Disease in Postmenopausal Patients with Early Breast Cancer: A Propensity Score‐Matched Cohort Study
Jung Il Lee, Jung‐Hwan Yu, Sung Gwe Anh, Hyun Woong Lee, Joon Jeong, Kwan Sik Lee
The Oncologist 2019; 24:e653-e661; first published on January 24, 2019; doi:10.1634/theoncologist.2018-0370


Gastrointestinal Cancer

胃肠胰神经内分泌癌的当前治疗方案
Current Treatment Options in Gastroenteropancreatic Neuroendocrine Carcinoma
Katharine E.H. Thomas, Brianne A. Voros, J. Philip Boudreaux, Ramcharan Thiagarajan, Eugene A. Woltering, Robert A. Ramirez
The Oncologist 2019; 24:1076-1088; first published on January 11, 2019; doi:10.1634/theoncologist.2018-0604

改进奥沙利铂辅助化疗在临床 II 期或 III 期直肠腺癌中的应用
Refining the Use of Adjuvant Oxaliplatin in Clinical Stage II or III Rectal Adenocarcinoma
Ofer Margalit, Ronac Mamtani, Scott Kopetz, Yu‐Xiao Yang, Yaacov R. Lawrence, Samir Abu‐Gazala, Kim A. Reiss, Talia Golan, Naama Halpern, Dan Aderka, Bruce Giantonio, Einat Shacham‐Shmueli, Ben Boursi
The Oncologist 2019; 24:e671-e676; first published on January 29, 2019; doi:10.1634/theoncologist.2018-0333

食管鳞状细胞癌淋巴细胞减少症:与营养不良、各种疾病指标及同步放化疗反应的关系
Lymphopenia in Esophageal Squamous Cell Carcinoma: Relationship to Malnutrition, Various Disease Parameters, and Response to Concurrent Chemoradiotherapy
Xi‐Lei Zhou, Wei‐Guo Zhu, Zhi‐Jian Zhu, Wan‐Wei Wang, Xue Deng, Wei‐Jing Tao, Fu‐Zhi Ji, Yu‐Suo Tong
The Oncologist 2019; 24:e677-e686; first published on April 30, 2019; doi:10.1634/theoncologist.2018-0723

FOLFIRI 联合阿帕西普 (Aflibercept) 治疗晚期结直肠癌的预后列线图及模式:真实世界数据分析
Prognostic Nomogram and Patterns of Use of FOLFIRI‐Aflibercept in Advanced Colorectal Cancer: A Real‐World Data Analysis
Ana Fernández Montes, Carlos López López, Guillem Argilés Martínez, David Páez López, Ana María López Muñoz, Beatriz García Paredes, David Gutiérrez Abad, Carmen Castañón López, Paula Jiménez Fonseca, Javier Gallego Plazas, María Carmen López Doldán, Eva Martínez de Castro, Manuel Sánchez Cánovas, María Tobeña Puyal, Beatriz Llorente Ayala, Ignacio Juez Martel, Mariana López Flores, Alberto Carmona‐Bayonas
The Oncologist 2019; 24:e687-e695; first published on May 30, 2019; doi:10.1634/theoncologist.2018-0824

位于左侧还是右侧真的很重要:替代生物标记物在解剖位置预测结直肠癌预后
Sidedness Matters: Surrogate Biomarkers Prognosticate Colorectal Cancer upon Anatomic Location
Irit Ben‐Aharon, Tal Goshen‐Lago, Michal Sternschuss, Sara Morgenstern, Ravit Geva, Alexander Beny, Ygael Dror, Mariana Steiner, Ayala Hubert, Efraim Idelevich, Katerina Shulman, Moshe Mishaeli, Sophia Man, Nicky Liebermann, Lior Soussan‐Gutman, Baruch Brenner
The Oncologist 2019; 24:e696-e701; first published on February 12, 2019; doi:10.1634/theoncologist.2018-0351


Hepatobiliary

双结节型肝细胞癌肝切除术后的长期生存预后情况:一项多中心队列研究
Long‐Term Survival Outcomes After Liver Resection for Binodular Hepatocellular Carcinoma: A Multicenter Cohort Study
Ming‐Da Wang, Chao Li, Jun Li, Wan‐Guang Zhang, Wei‐Qin Jiang, Jiong‐Jie Yu, Hao Xing, Han Wu, Jun Han, Zhen‐Li Li, Xin‐Fei Xu, Ting‐Hao Chen, Ya‐Hao Zhou, Wei‐Min Gu, Hong Wang, Yong‐Yi Zeng, Yao‐Ming Zhang, Timothy M. Pawlik, Wan Yee Lau, Meng‐Chao Wu, Jia‐Mei Yang, Feng Shen, Tian Yang
The Oncologist 2019; 24:e730-e739; first published on May 24, 2019; doi:10.1634/theoncologist.2018-0898


Lung Cancer

司里班妥单抗联合厄洛替尼治疗 EGFR 野生型非小细胞肺癌的随机 II 期试验
Randomized Phase II Trial of Seribantumab in Combination with Erlotinib in Patients with EGFR Wild‐Type Non‐Small Cell Lung Cancer
Lecia V. Sequist, Jhanelle Elaine Gray, Wael A. Harb, Ariel Lopez‐Chavez, Robert C. Doebele, Manuel R. Modiano, David Michael Jackman, Maria Quintos Baggstrom, Akin Atmaca, Enriqueta Felip, Mariano Provencio, Manuel Cobo, Bambang Adiwijaya, Geoffrey Kuesters, Walid S. Kamoun, Karen Andreas, J. Marc Pipas, Sergio Santillana, Byoung Chul Cho, Keunchil Park, Frances A. Shepherd
The Oncologist 2019; 24:1095-1102; first published on April 11, 2019; doi:10.1634/theoncologist.2018-0695

劳拉替尼不良事件的临床管理
Clinical Management of Adverse Events Associated with Lorlatinib
Todd M. Bauer, Enriqueta Felip, Benjamin J. Solomon, Holger Thurm, Gerson Peltz, Marc D. Chioda, Alice T. Shaw
The Oncologist 2019; 24:1103-1110; first published on March 19, 2019; doi:10.1634/theoncologist.2018-0380

采用免疫检查点抑制剂药物治疗晚期非小细胞肺癌中外周血标志物对于免疫相关毒性风险的识别价值
Peripheral Blood Markers Identify Risk of Immune‐Related Toxicity in Advanced Non‐Small Cell Lung Cancer Treated with Immune‐Checkpoint Inhibitors
Alberto Pavan, Lorenzo Calvetti, Alessandro Dal Maso, Ilaria Attili, Paola Del Bianco, Giulia Pasello, Valentina Guarneri, Giuseppe Aprile, PierFranco Conte, Laura Bonanno
The Oncologist 2019; 24:1128-1136; first published on April 23, 2019; doi:10.1634/theoncologist.2018-0563

NUT 癌的临床病理和临床前研究发现:一项多中心研究
Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study
Minsun Jung, Soyeon Kim, June‐Koo Lee, Sun Och Yoon, Heae Surng Park, Soon Won Hong, Weon‐Seo Park, Ji Eun Kim, Joon Kim, Bhumsuk Keam, Hyun Jik Kim, Hyoung Jin Kang, Dong‐Wan Kim, Kyeong Cheon Jung, Young Tae Kim, Dae Seog Heo, Tae Min Kim, Yoon Kyung Jeon
The Oncologist 2019; 24:e740-e748; first published on January 29, 2019; doi:10.1634/theoncologist.2018-0477

第 8 版肺癌 TNM 分期 M1b 疾病:单发胸外远处转移模式及临床预后
M1b Disease in the 8th Edition of TNM Staging of Lung Cancer: Pattern of Single Extrathoracic Metastasis and Clinical Outcome
Hyesun Park, Suzanne E. Dahlberg, Christine A. Lydon, Tetsuro Araki, Hiroto Hatabu, Michael S. Rabin, Bruce E. Johnson, Mizuki Nishino
TThe Oncologist 2019; 24:e749-e754; first published on January 29, 2019; doi:10.1634/theoncologist.2018-0596